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Open Restricted Access Barrier System – ORABS

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Open Restricted Access Barrier System – ORABS

An Open Restricted Access Barrier System (ORABS) is a type of containment system used in pharmaceutical manufacturing and research to prevent cross-contamination and protect against the release of hazardous materials. ORABS typically consists of a combination of physical barriers, such as walls, doors, and windows, and engineering controls, such as air filtration and ventilation systems, to create a controlled environment for handling potentially hazardous substances. ORABS are commonly used in the production of sterile and high-potency drugs, as well as in research laboratories and other facilities where the risk of exposure to hazardous materials is high.
ORABS consists of a series of barriers or partitions that are placed around a specific area within a cleanroom. These barriers are made of materials such as plastic or metal and are designed to create a physical barrier between the cleanroom environment and the outside world. ORABS typically have access ports or doors that allow people or equipment to enter and exit the controlled area.

ORABS are designed to maintain a specific level of cleanliness within the controlled area. They use a combination of air filtration and air flow control to keep the air clean and free of contaminants. This can help to prevent contamination of sensitive materials or products and ensure that they maintain their purity and quality.

In addition to maintaining a clean environment, ORABS can also help to reduce the risk of cross-contamination between different areas within a cleanroom. This can be particularly important in industries such as pharmaceuticals, where different products may need to be manufactured in different areas within the same cleanroom. By using ORABS, it is possible to create separately controlled environments within a cleanroom, which can help to reduce the risk of cross-contamination.
To measure wind speed, differential pressure, cleanliness, and other factors, ORABS can create custom online monitoring systems. ORABS does not offer standard products; all items are created from the URS provided by the buyer. It is often found in laboratories or pharmaceutical facilities for tasks such as handling and processing drugs and other materials. ORABS are designed to be a self-contained workspace, free from pollutants, and are often equipped with a ventilation system to help keep the air clean. In addition, ORABS may have features such as cleaning benches and fume hoods to help prevent the release of potentially hazardous materials. ORABS has also been designed as an open workspace, allowing easy access and movement within the workspace while still maintaining a high level of cleanliness and preventing contamination.

What is an open restricted access barrier system used for?

An open restricted access barrier system (RABS) is a type of containment system used in pharmaceutical and biotechnology manufacturing to protect against contaminants and maintain a clean and controlled environment. RABS are designed to provide an additional layer of protection against contamination in the manufacturing process, while still allowing operators to easily access the product.

RABS are typically used in the production of parenteral products (e.g. injectable drugs) and other high-risk products that are particularly sensitive to contamination. They are also used in aseptic filling operations, where products are filled into containers in a sterile environment to prevent contamination.

RABS typically consist of a barrier or wall that surrounds the production area, with a separate operator area on the other side. The barrier is equipped with gloves or other access ports that allow operators to manipulate the product without coming into direct contact with it. This helps to prevent contamination from operators and the surrounding environment, while still allowing for easy access to the product.

How to choose an open restricted access barrier system for your cleanroom projects?

There are a few key factors to consider when choosing an open restricted access barrier system (RABS) for your cleanroom projects:

  1. Size and capacity: Consider the size of the space you need to contain and the level of cleanliness required (e.g. ISO Class 5, 6, 7). This will help you determine the appropriate size and number of RABS units needed.
  2. Containment capabilities: Look for a RABS with strong containment capabilities to ensure that contaminants are kept out of the cleanroom environment.
  3. Ease of use: Choose a RABS that is easy for your operators to use, with clear instructions and intuitive controls.
  4. Maintenance requirements: Consider the ease of maintenance and availability of replacement parts for the RABS you choose.
  5. Cost: Determine your budget and look for a RABS that fits within it, while still meeting your needs and requirements.

It may also be helpful to consult with a cleanroom specialist or manufacturer to discuss your specific needs and get recommendations for the best open RABS for your project.

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