02. Portable Decontamination VHP Generator Unit

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Mobile VHP Sterilization System – Decontamination and Disinfection Generator

02. Portable Decontamination VHP Generator Unit

What is the VHP Sterilizer for Cleanroom?

VHP Sterilizers: Precision Cleanliness

  • Utilizes vaporized hydrogen peroxide for effective sterilization.
  • Releases a mist of VHP to eliminate bacteria, viruses, fungi, and other pathogens.
  • Commonly employed in medical facilities, labs, and areas requiring high sanitation.
  • Capable of sterilizing a variety of materials, such as medical devices, surfaces, and room air.
  • Safe operation without leaving harmful residues post-sterilization.
  • In cleanrooms, VHP gas circulates to sterilize the entire area.
  • Ideal for use in controlled environments to maintain cleanliness and prevent contamination.

YOUTH VHP Generator: Advanced Decontamination

  • Developed for equipment internal sterilization and cleanroom decontamination.
  • Advanced vaporization process of hydrogen peroxide for complete sterilization.
  • Harnesses the enhanced bactericidal and sporicidal properties of VHP at room temperature.
  • Extensively applied for sterilizing isolators, transfer hatches, and pass-through chambers.
  • Suitable for bag-in/bag-out systems and spaces adhering to GMP standards.
  • Ensures a contaminant-free setting for sensitive operations and critical tasks.

Benefits of Cleanroom VHP Sterilizer

Sterilization of Medical Equipment
Cleanroom VHP Sterilizer is a reliable and effective method of sterilizing medical equipment. This technology is crucial in preventing the spread of infections in hospitals and healthcare facilities. The VHP method of sterilization is fast, efficient, and safe for patients and healthcare workers.

Increased Efficiency
Cleanroom VHP Sterilizer is a cost-effective and efficient method of sterilizing surfaces and equipment in cleanrooms. The VHP method of sterilization is fast and requires minimal downtime, which translates to increased productivity.

Cleanroom VHP Sterilizer is a cost-effective method of sterilizing surfaces and equipment. The VHP method of sterilization requires minimal maintenance, and the equipment has a long lifespan. The cost of maintenance and support is minimal compared to other sterilization methods.

Comparison of
vaporization and atomization sterilization methods

Different Methods of VHP Sterilization


DifferenceVaporized hydrogen peroxide decontaminationAtomized hydrogen peroxide decontamination
Hydrogen peroxide solution30~35%<8%
GeneratedFlash steaming/heating vaporizationPressure/ultrasound/rotary flap
Sterilization mechanismThe vaporization process is controlled below the VHP condensation point to ensure that hydrogen peroxide is in a gaseous state and the gas diffuses to air and surface sterilization The atomization process keeps small droplets of hydrogen  peroxide in the air to achieve the purpose of sterilization
UniformityUniform distribution and good dispersion performanceAgglomerates into small droplets with uneven distribution
ControlIn the adjustment stage, the VHP concentration is controlled to rise to the sterilization concentration in an increasing form, and the VHP concentration and humidity are strictly controlled during the sterilization stageWith only the atomization effect, it is not easy to achieve precise control
Sterilization timeIt depends on the size of the spaceAfter the disinfection is completed, it needs to stand for about 1~2h
Discharge timeHydrogen peroxide remains vaporized and therefore has a shorter emission time.Disinfectants attached to the surface of objects are not easy to remove.
CorrosiveThe effect on the material is relatively mildA high concentration of hydrogen peroxide condensed liquid is relatively corrosive on the contact surface
Bactericidal effect6-log4-log to 6-log
Sterilization broad-spectrumClostridium difficile, MRSA, VRE, Acinetobacter bauncei and virusesMRSA and Acinetobacter bougonii, etc
Surface residueLowerHigher
Consistency of sterilizationBased on the consistency of gas distribution and high diffusivity, good distribution control can be obtainedVaries depending on the uniformity of the distribution of relative humidity, temperature, and concentration in the room

What are the Differences Between VHP and DHP Sterilizer?

Both VHP and DHP are commonly used as disinfection methods in cleanroom environments, but they differ in their application and delivery.

  • Vaporized Hydrogen Peroxide (VHP): VHP involves the generation of a fine mist or vapor of hydrogen peroxide that is distributed throughout the cleanroom space. VHP systems typically consist of a generator or vaporizer that converts liquid hydrogen peroxide into a vapor, which is then dispersed throughout the cleanroom using specialized equipment. The vaporized hydrogen peroxide is effective in disinfecting surfaces, equipment, and the air within the cleanroom.
  • Dry Hydrogen Peroxide (DHP):  also known as aerosolized hydrogen peroxide or hydrogen peroxide gas plasma, is a method where hydrogen peroxide is converted into a gas or plasma state. DHP systems use specialized generators to produce the gas or plasma, which is then introduced into the cleanroom environment. The gas or plasma interacts with the contaminants and surfaces within the cleanroom, leading to disinfection.

While both VHP and DHP utilize hydrogen peroxide for disinfection, their main difference lies in the state of hydrogen peroxide used (vapor vs. gas/plasma) and the methods of delivery. VHP relies on vaporizing liquid hydrogen peroxide, while DHP involves the generation of a gas or plasma from hydrogen peroxide. The choice between VHP and DHP depends on factors such as the specific cleanroom requirements, the size and configuration of the cleanroom, and the desired disinfection efficacy.

VHP Produces Oxygen-Free Radicals by Vaporizing

hydrogen peroxide solution to act on microorganisms on the surface and environment, which specifically destroys the cell structure and has a broad-spectrum bactericidal effect. It is necessary to control the humidity of the sterilized space to avoid condensation caused by excessive VHP water content.

Dry sterilization process

  • Dehumidification – The relative humidity of the space is reduced to the parameter set point so that the air can act as a carrier for hydrogen peroxide gas and the concentration of hydrogen peroxide gas is maintained above the saturated dew point level during the sterilization phase.
  • Conditioning – Hydrogen peroxide gas is continuously injected into the dry air stream, replacing the air in the sterilized environment, so that the hydrogen peroxide concentration continues to rise rapidly.
  • Decontamination – Maintain the concentration of hydrogen peroxide gas required for sterilization and control humidity during sterilization Aeration Stop the injection of hydrogen peroxide gas, replace the air in the environment, and crack hydrogen peroxide through the lysate to discharge all hydrogen peroxide.

Wet Sterilization Process

  • Conditioning – Hydrogen peroxide gas is continuously injected into the dry air stream, replacing the air in the sterilized environment, so that the hydrogen peroxide concentration continues to rise rapidly.
  • Decontamination – Maintain the concentration of hydrogen peroxide gas required for sterilization Aeration Stop hydrogen peroxide gas injection, replace the air in the environment, and crack it with the lysate.

Different Sterilization Process

Dry methodWet method
Humidity control throughout each stage of the cycleNo need to control humidity
No supersaturated steam, no condensation generationThe saturated steam is too high, and it is slightly condensed
Dry gaseous hydrogen peroxide is light in weight, easy to diffuse, and evenly distributedMicrodroplet hydrogen peroxide weighs heavily, is not   easy to diffuse, and is unevenly distributed
The sterilization concentration can be set to achieve uniformityThe sterilization concentration needs to be high and not easy to control
The process is repeatableThe condensation point is difficult to control and the repeatability is not strong

Different Removal of Residue and Residue

Dry methodWet method
No condensation and faster drainageCoagulation makes the debris removal process longer than that of the dry sterilization process
Gaseous hydrogen peroxide is discharged quickly and has no residueThe surface residue is large and corrosive

Different Verification Method

Dry methodWet method
The distribution of biological indicators and the culture results were representativeThere are few verification points, and the results are not representative
Highly reproducible validationWeak reproducibility

Different Sterilization Effect

Dry methodWet method
Highly permeable, can penetrate HEPA for efficient sterilizationThe permeability is poor, and HEPA is difficult to sterilize efficiently
High repeatabilityWeak repeatability
Good sterilization effect and consistencyThe sterilization effect is difficult to standardize, sometimes good and bad, and it is not easy to   design the sterilization program

YOUTH's VHP Tech is Safe, Controllable, and Reliable.

The concentration of hydrogen peroxide is expertly regulated to maintain uniform levels during the entire sterilization cycle, remaining non-condensing to ensure superior compatibility with a wide range of materials. This meticulous control notably reduces the potential for corrosion, safeguarding equipment integrity.
A thorough and methodical assessment of the compatibility with color steel plates is conducted to ensure seamless integration. The results of this evaluation are meticulously compiled into a detailed report, underlining our commitment to quality and material compliance.

Report of YOUTH's VHP Generator

YOUTH’s chosen hydrogen peroxide sterilization method is recognized for its safety, precision, and dependability.

  • It is critical to monitor the temperature at the output of the hydrogen peroxide generator, manage integration risks with various environments, and prevent local condensation during operation. Ensuring homogeneous vertical dispersion of hydrogen peroxide is also essential for effectiveness.
  • The generator’s outlet design demands versatility to adapt to diverse scenarios and conditions. It should provide options to selectively seal or modulate the aperture based on situational needs, preventing high-concentration hydrogen peroxide vapor from directly contacting color steel plates, thereby safeguarding against localized corrosion.
  • Post-sterilization, the degradation process of hydrogen peroxide (including options for catalytic degradation at low concentrations before initiating ventilation) should be chosen with a view towards minimizing risk and promoting eco-friendliness, thereby mitigating the residual discharge’s impact on HVAC systems and the surrounding environment.

Hydrogen Peroxide Drainage (Optional)

The hydrogen peroxide degradation mechanism is customizable, activating the HPSD system post-sterilization to break down hydrogen peroxide vapors within the area. For instance, the system may reduce levels to 10ppm before engaging the HVAC system to cycle in fresh air, thereby diminishing the corrosive impact of hydrogen peroxide on cleanroom HVAC systems and ductwork. Traditional methods of air exchange and venting can lead to condensation in cool external environments and demand greater corrosion resistance from the air conditioning systems and their associated piping.

Hydrogen peroxide space decontamination concerns

Robust Compliance with Global Standards

Adherence to global health and safety regulations is at the forefront of the Mobile Decontamination VHP Generator System design. Fully compliant with Good Manufacturing Practices (GMP) and other pertinent regulations, this system offers a sophisticated hydrogen peroxide sterilization technology that assures safety with its mature and repeatable process. Special chemical and biological indicators are utilized to monitor the distribution of hydrogen peroxide, cementing the system’s robustness in maintaining sterility at the highest assurance levels.


Sophisticated User Access Management

To meet rigorous audit trail requirements and FDA 21CFR Part 11 standards for electronic records and signatures, the system is equipped with a layered user management framework comprising administrator, technician, and operator privileges. This delineation of rights ensures secure and traceable access control while maintaining the integrity of sterilization data.


Data Management and Reporting

The Mobile VHP Generator System exhibits unmatched excellence in capturing and presenting sterilization process data. It compiles comprehensive reports, alarm records, operation logs, and data curves, which can all be efficiently exported in PDF format for easy archiving and sharing. Furthermore, compliance with OPC/Modbus communication protocols highlights its readiness to integrate with Laboratory Information Management Systems (LIMS), Building Management Systems (BMS), Manufacturing Execution Systems (MES), and Supervisory Control And Data Acquisition (SCADA) networks.


Innovative Technology and Material Compatibility

The system is ingeniously designed to eliminate any corrosion risk in the sterilization process, owing to its non-condensing nature and compatibility with a wide array of materials including color steel plates and sensitive electronic instruments. Advanced signal shielding is ingeniously countered by an industrial-grade wireless module, ensuring seamless wireless connectivity to the control system, avoiding common pitfalls associated with traditional wireless routers ensnared by signal isolation issues.


Consistency and Stability

Uniformity in hydrogen peroxide dispersion is paramount for consistent decontamination, and the Mobile VHP Generator System delivers on this front with unwavering reliability. By ensuring the uniform spread of VHP, it nullifies pockets of bio-burden that often challenge the industry’s mandate for contamination-free environments.


Environmental Considerations

The system’s controlled emissions have minimal impact on HVAC systems and their corresponding ductwork, demonstrating an eco-conscious approach that doesn’t compromise sterilization effectiveness. Stability issues related to remote control and data transmission are confidently addressed through technology that ensures uninterrupted operations.
Multiple Equipment Group Control Center

Multiple Equipment Group Control of VHP Generator

Multiple Equipment Group Control Center

Vaporized hydrogen peroxide generator, supports remote wireless control, and can realize multiple equipment group control, single or multiple equipment simultaneous start and stop control, truly achieving remote supervision. The adjustable nozzle device can spray hydrogen peroxide gas at multiple angles, which can diffuse to the dead corner of the sterilization area to ensure full coverage of the sterilization area.


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