VHP (Vaporized Hydrogen Peroxide) H2O2 Pass Box

Categories - Pass Box / Pass-Through

What is a Cleanroom VHP Pass Box?

The VHP pass box serves as a crucial tool for transferring small items between clean areas, as well as between non-clean areas and clean areas. Its primary function is to minimize the number of door openings within the clean room, thereby reducing the risk of contamination in clean areas. VHP pass boxes find extensive applications in various settings such as micro-technology, biological laboratories, pharmaceutical factories, hospitals, and food processing plants.

Sterilization technology employed in VHP pass boxes utilizes a unique flash evaporation system. This system ensures the uniform distribution of VHP liquid within the cavity, optimizing the evaporation process. As a result, it achieves higher and more stable VHP gas concentrations, greatly enhancing the effectiveness and efficiency of sterilization.

To achieve a complete seal, the VHP pass box incorporates advanced sealing technology. It features a stainless steel frame with double-layer 5mm tempered glass doors. A silicone inflatable sealing strip is utilized to seal the pass box, ensuring airtight closure. The adoption of insulating double-layer glass also enhances the pass box’s thermal insulation performance.

10 Benefits of YOUTH VHP Pass Box:

Low-temperature sterilization process: Enables disinfection and sterilization at room temperature, making it suitable for products that cannot withstand high temperatures.
100% improvement over traditional gasified VHP pass boxes: Offers enhanced performance and functionality compared to conventional models.
Combination of inflatable sealing system and electromagnetic interlock: Prevents VHP gas leakage and contamination caused by door openings simultaneously.
Intelligent control system: User-friendly interface and intuitive operation for convenient and fast application, resulting in improved efficiency.
Environmentally friendly: Leaves no environmental pollution or residues. Final byproducts are water and oxygen, which can be quickly decomposed.
Compliance with latest GMP requirements: Meets the latest standards, ensuring good process repeatability and facilitating verification tests.
Operator and environment-friendly: No harm to operators, no environmental pollution, and no impact on other items such as devices, electrical appliances, or clean room wall panels.
Cost savings: Reduces process cycle times, improves sterilization efficiency, and lowers energy and consumable consumption, resulting in cost savings.
Effective sterilization: Achieves efficient and uniform killing of Bacillus stearothermophilus Lg6.
Diversified professional sterilization solutions: Provides users with a wide range of sterilization options tailored to meet specific customer needs. These solutions are more efficient, simpler, and more convenient than ordinary hydrogen oxide pass boxes.

Technical Descriptions of YOUTH’s VHP Pass Box (8 Key Features):

All-in and all-exhaust exhaust method: Ensures maximum purification efficiency and provides a sealed VHP sterilization stage.
Flow rate: 50L/min
Consumption: 1 cubic unit
Dew point: -20℃
Maximum particle size: < 0.5um
Sterilization efficiency exceeds 6Lg.
VHP integration: Incorporates VHP (Vaporized Hydrogen Peroxide) technology for effective sterilization.
Online concentration control: Monitors and controls VHP gas concentration in real-time during the sterilization process.
Air volume of 400-500m³/H: Supplies fresh air to the room, ensuring proper ventilation.
Slightly positive working pressure: Maintains a slight positive pressure inside the pass box for optimal performance.
Sterilization process
1. Preparation stage: place items, close the warehouse door.
2. Condition stage: turn on the dehumidifier, turn on the heater of the sterilizer (automatic switch according to the set temperature), judge that the current humidity of the equipment is ≤ 25% , and the conditions are met to go to the next stage.
3. Pre-sterilization stage: turn on the peristaltic pump, quickly increase the cavity concentration.
4. Sterilization stage: turn on the peristaltic pump, enter a small amount of H2O2 to make the concentration reach saturation.
5. Maintain stage: turn off the peristaltic pump and heater, (time control) .
6. Ventilation stage: open the air intake and exhaust, control the cavity pressure, when the pressure is stable, the exhaust air can be opened to the maximum.

VHP Concentration/Time Schematic:

Entry Phase (Humidification): VHP concentration starts to increase rapidly.
Boost Phase (Adjustment): VHP concentration rapidly reaches sterilizing conditions.
Hold Phase (Sterilization): VHP concentration gradually decays, allowing it to be maintained for a specific duration.
Residual Removal Stage (Ventilation): VHP concentration in the air is displaced, decomposing into residual free water and oxygen.
In the whole sterilization process, the size of the sterilization to be sterilized, gas concentration, humidity, temperature, biological indicator sterilization curve and time, all affect the sterilization cycle, so according to the site conditions, we need to develop a series of parameters , to provide customers with the best parameters, thus saving time and operating costs.
Compared with traditional sterilization methods, VHP sterilization has the following technical characteristics:
Low temperature sterilization process (4-80℃)
Very little residue after the sterilization process (no need to clean again)
No Toxic By-Products After Evacuation (Health & Safety)
The process is very easy to verify, and each link is controllable (compound regulatory requirements, easy to control)
Environmental Protection (Health & Safety & Environmental Protection)
Good penetration to high efficiency filters
Good compatibility with materials
Low temperature sterilization process, disinfection and sterilization can be carried out at room temperature, and used for products that cannot be sterilized at high temperature
Using the flash evaporation system, the conversion efficiency is improved by more than 100% compared with the traditional gasification VHP pass box
The combination of inflatable sealing system and electromagnetic interlock can avoid the leakage of VHP gas and the pollution caused by opening the door at the same time, which is safer
The intelligent control system, simple and intuitive operation interface, and more friendly human-machine dialogue design can make the application operation more convenient and fast, thus bringing about more accurate lethal efficiency.
No pollution to the environment and no residues. The final products are water and oxygen. When the residues are discharged, the heat of the heat preservation can help the VHP to be quickly decomposed into water and oxygen.
In line with the latest version of GMP requirements, the process has good repeatability and is easy to pass the verification test.
No harm to operators, no pollution to the environment, no impact on other items (devices, electrical appliances, clean room wall panels, etc.).
Excellent sterilization effect, which can effectively and uniformly kill Bacillus stearothermophilus Lg6.

what are the Applications of Cleanroom VHP Pass Boxes?

A. Pharmaceutical Industry

Cleanroom VHP pass boxes find extensive use in the pharmaceutical industry. They are utilized for transferring raw materials, equipment, and finished products into and out of cleanrooms. The pass boxes play a crucial role in preventing cross-contamination and maintaining the sterility of pharmaceutical products.

B. Biotechnology Industry

In the biotechnology industry, cleanroom VHP pass boxes are utilized for the transfer of sensitive biological materials, such as cell cultures, media, and laboratory equipment. The pass boxes ensure that the integrity of these materials is preserved and the risk of contamination is minimized during transportation.

C. Semiconductor Industry

The semiconductor industry demands stringent cleanliness standards to prevent any particle contamination that could impact the performance of microelectronic devices. Cleanroom VHP pass boxes are used to transfer delicate components, tools, and equipment into cleanrooms where semiconductors are manufactured or assembled, safeguarding against contamination.

D. Food and Beverage Industry

In the food and beverage industry, cleanroom VHP pass boxes are employed for the transfer of sterile packaging materials, food ingredients, and sensitive equipment. These pass boxes help maintain the cleanliness and quality of food products by minimizing the risk of microbial contamination during transportation.

Youth's Customized Feature For VHP Pass Box

Youth’s VHP Pass-Box is controlled by SIEMENS automation control equipment, ensuring stable operation throughout all stages of the process. This advanced control system ensures reliable and efficient performance, meeting the high standards and requirements of our international clients.

During the biological decontamination and exhaust stages, all gases introduced into the chamber are filtered through H14-grade HEPA filters to prevent any material contamination.

Our system features an independent ventilation and exhaust unit, including fans, pneumatic butterfly valves, and exhaust pipelines. This allows for rapid replacement of the hydrogen peroxide gas inside the chamber, preventing it from entering the HVAC system.

The inlet and outlet are designed with double-door structures, featuring pneumatic sealing, locking, and interlocking mechanisms to ensure safe operation. The doors are interlocked when the system is in operation.

The system has real-time monitoring capabilities for temperature, humidity, and pressure inside the cabin. The sterile transfer chamber is equipped with complete IQ, OQ, PQ documentation and can provide on-site validation.